Title: Harnessing the potential of epigenetic therapy to target solid tumors.

Authors: Ahuja, Nita; Easwaran, Hariharan; Baylin, Stephen B

Published In J Clin Invest, (2014 Jan)

Abstract: Epigenetic therapies may play a prominent role in the future management of solid tumors. This possibility is based on the clinical efficacy of existing drugs in treating defined hematopoietic neoplasms, paired with promising new data from preclinical and clinical studies that examined these agents in solid tumors. We suggest that current drugs may represent a targeted therapeutic approach for reprogramming solid tumor cells, a strategy that must be pursued in concert with the explosion in knowledge about the molecular underpinnings of normal and cancer epigenomes. We hypothesize that understanding targeted proteins in the context of their enzymatic and scaffolding functions and in terms of their interactions in complexes with proteins that are targets of new drugs under development defines the future of epigenetic therapies for cancer.

PubMed ID: 24382390

MeSH Terms: Antineoplastic Agents/pharmacology*; Antineoplastic Agents/therapeutic use; DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methylation; Epigenesis, Genetic*; Genome, Human; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylase Inhibitors/therapeutic use; Humans; Molecular Targeted Therapy; Neoplasms/drug therapy*; Neoplasms/enzymology; Neoplasms/genetics