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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia.

Authors: Harmon, Quaker E; Engel, Stephanie M; Wu, Michael C; Moran, Thomas M; Luo, Jingchun; Stuebe, Alison M; Avery, Christy L; Olshan, Andrew F

Published In Am J Reprod Immunol, (2014 May)

Abstract: Inflammatory biomarkers are associated with preeclampsia (PE) and poor fetal growth; however, genetic epidemiologic studies have been limited by reduced gene coverage and the exclusion of African American mothers.Cases and controls (N = 1646) from a pregnancy cohort were genotyped for 503 tagSNPs in 40 genes related to inflammation. Gene-set analyses were stratified by race and were followed by a single SNP analysis within significant gene sets.Gene-level associations were found for IL6 and KLRD1 for term small for gestational age (SGA) among African Americans. LTA/TNF and TBX21 were associated with PE among European Americans. The strongest association was for PE among European Americans for an upstream regulator of TNF with RR = 1.8 (95% CI 1.1-2.7).Although previous studies have suggested null associations, increased tagging and stratification by genetic ancestry suggests important associations between IL6 and term SGA for African Americans, and a TNF regulator and PE among European Americans (N = 149).

PubMed ID: 24702779 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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