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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Genome-wide association study of smoking behaviours among Bangladeshi adults.

Authors: Argos, Maria; Tong, Lin; Pierce, Brandon L; Rakibuz-Zaman, Muhammad; Ahmed, Alauddin; Islam, Tariqul; Rahman, Mahfuzar; Paul-Brutus, Rachelle; Rahaman, Ronald; Roy, Shantanu; Jasmine, Farzana; Kibriya, Muhammad G; Ahsan, Habibul

Published In J Med Genet, (2014 May)

Abstract: The high prevalence of tobacco use in some developing nations, including Bangladesh, poses several public health challenges for these populations. Smoking behaviour is determined by genetic and environmental factors; however, the genetic determinants of smoking behaviour have not been previously examined in a Bangladeshi or South Asian population. We performed a genome-wide association study (GWAS) of tobacco smoking behaviour among a population-based sample of 5354 (2035 ever smokers and 3319 never smokers) men and women in Bangladesh.Genome-wide association analyses were conducted for smoking initiation (ever vs never smokers), smoking quantity (cigarettes per day), age of smoking initiation, and smoking cessation (former vs current smokers). Sex-stratified associations were performed for smoking initiation.We observed associations for smoking initiation in the SLC39A11 region at 17q21.31 (rs2567519, p=1.33×10⁻⁷) among men and in the SLCO3A1 region at 15q26 (rs12912184, p=9.32×10⁻⁸) among women.These findings suggest possible underlying mechanisms related to solute carrier transporter genes, which transport neurotransmitters, nutrients, heavy metals and other substrates into cells, for smoking initiation in a South Asian population in a sex-specific pattern. Genetic markers could have potential translational implications for the prevention or treatment of tobacco use and addiction in South Asian populations and warrant further exploration.

PubMed ID: 24665060 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Aged; Bangladesh; Female; Genome-Wide Association Study; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide*; Smoking Cessation; Smoking/genetics*; Young Adult

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