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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells.

Authors: Sharma, Vyom; Collins, Leonard B; Clement, Jean M; Zhang, Zhenfa; Nakamura, Jun; Swenberg, James A

Published In Chem Res Toxicol, (2014 Apr 21)

Abstract: For DNA-reactive chemicals, a low dose linear assessment of cancer risk is the science policy default. In the present study, we quantitated the endogenous and exogenous N7-methyl-G and O(6)-methyl-dG adducts in human lymphoblastoid cells exposed to low dose [D3]-methylnitrosourea. Endogenous amounts of both adducts remained nearly constant, while the exogenous adducts showed linear dose-responses. The data show that O(6)-methyl-dG adducts ≥1.8/10(8) dG correlated with published studies that demonstrated significant increases of mutations under these conditions. The combined results do not support linear extrapolations to zero when data are available for science-based regulations.

PubMed ID: 24628573 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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