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National Institute of Environmental Health Sciences

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Publication Detail

Title: Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population.

Authors: Hernandez, Brenda Y; Goodman, Marc T; Unger, Elizabeth R; Steinau, Martin; Powers, Amy; Lynch, Charles F; Cozen, Wendy; Saber, Maria Sibug; Peters, Edward S; Wilkinson, Edward J; Copeland, Glenn; Hopenhayn, Claudia; Huang, Youjie; Watson, Meg; Altekruse, Sean F; Lyu, Christopher; Saraiya, Mona; HPV Typing of Cancer Workgroup

Published In Front Oncol, (2014)

Abstract: BACKGROUND: Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited. METHODS: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review. RESULTS: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status. CONCLUSION: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.

PubMed ID: 24551592 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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