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Publication Detail

Title: Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.

Authors: Martin, Ciara A; Krantz, David E

Published In Neurochem Int, (2014 Jul)

Abstract: The model genetic organism Drosophila melanogaster, commonly known as the fruit fly, uses many of the same neurotransmitters as mammals and very similar mechanisms of neurotransmitter storage, release and recycling. This system offers a variety of powerful molecular-genetic methods for the study of transporters, many of which would be difficult in mammalian models. We review here progress made using Drosophila to understand the function and regulation of neurotransmitter transporters and discuss future directions for its use.

PubMed ID: 24704795 Exiting the NIEHS site

MeSH Terms: Animals; Cell Membrane/drug effects; Cell Membrane/metabolism; Drosophila Proteins/genetics*; Drosophila Proteins/metabolism; Drosophila melanogaster/metabolism*; Humans; Neurotransmitter Transport Proteins/drug effects; Neurotransmitter Transport Proteins/genetics*; Neurotransmitter Transport Proteins/metabolism; Vesicular Neurotransmitter Transport Proteins/genetics; Vesicular Neurotransmitter Transport Proteins/metabolism

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