Title: Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.
Authors: Lin, Zhenjian; Koch, Michael; Abdel Aziz, May Hamdy; Galindo-Murillo, Rodrigo; Tianero, Ma Diarey; Cheatham, Thomas E; Barrows, Louis R; Reilly, Chris A; Schmidt, Eric W
Published In Org Lett, (2014 Sep 19)
Abstract: A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.
PubMed ID: 25188821
MeSH Terms: No MeSH terms associated with this publication