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Publication Detail

Title: Immune-related conditions and acute leukemia in children with Down syndrome: a Children's Oncology Group report.

Authors: Linabery, Amy M; Li, Wenchao; Roesler, Michelle A; Spector, Logan G; Gamis, Alan S; Olshan, Andrew F; Heerema, Nyla A; Ross, Julie A

Published In Cancer Epidemiol Biomarkers Prev, (2015 Feb)

Abstract: Children with Down syndrome have unique immune profiles and increased leukemia susceptibility.Mothers of 158 children with Down syndrome diagnosed with acute leukemia at 0 to 19 years in 1997 to 2002 and 173 children with Down syndrome but no leukemia were interviewed. Associations were evaluated via multivariable unconditional logistic regression.No associations were detected for asthma, eczema, allergies, or hypothyroidism. Diabetes mellitus associated with leukemia (OR = 9.23; 95% confidence interval 2.33-36.59); however, most instances occurred concurrent with or after the leukemia diagnosis.Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors.

PubMed ID: 25499068 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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