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Publication Detail

Title: Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA.

Authors: Melton, Douglas; Lewis, Calvin D; Price, Nathan E; Gates, Kent S

Published In Chem Res Toxicol, (2014 Dec 15)

Abstract: Hydralazine (4) is an antihypertensive agent that displays both mutagenic and epigenetic properties. Here, gel electrophoretic, mass spectroscopic, and chemical kinetics methods were used to provide evidence that medicinally relevant concentrations of 4 rapidly form covalent adducts with abasic sites in double- and single-stranded DNA under physiological conditions. These findings raise the intriguing possibility that the genotoxic properties of this clinically used drug arise via reactions with an endogenous DNA lesion rather than with the canonical structure of DNA.

PubMed ID: 25405892 Exiting the NIEHS site

MeSH Terms: Antihypertensive Agents/chemistry*; Base Sequence; DNA, Single-Stranded/chemistry*; DNA/chemistry*; Hydralazine/chemistry*; Mass Spectrometry

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