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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Ah receptor and NF-kappaB interactions, a potential mechanism for dioxin toxicity.

Authors: Tian, Y; Ke, S; Denison, M S; Rabson, A B; Gallo, M A

Published In J Biol Chem, (1999 Jan 01)

Abstract: The Ah receptor (AhR) mediates many of the toxic responses induced by polyhalogenated and polycyclic hydrocarbons (PAHs) which are ubiquitous environmental contaminants causing toxic responses in human and wildlife. NF-kappaB is a pleiotropic transcription factor controlling many physiological functions adversely affected by PAHs, including immune suppression, thymus involution, hyperkeratosis, and carcinogenesis. Here, we show physical interaction and mutual functional repression between AhR and NF-kappaB. This mutual repression may provide an underlying mechanism for many hitherto poorly understood PAH-induced toxic responses, and may also provide a mechanistic explanation for alteration of xenobiotic metabolism by cytokines and compounds that regulate NF-kappaB.

PubMed ID: 9867872 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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