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National Institute of Environmental Health Sciences

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Publication Detail

Title: Coupling of human circadian and cell cycles by the timeless protein.

Authors: Unsal-Kaçmaz, Keziban; Mullen, Thomas E; Kaufmann, William K; Sancar, Aziz

Published In Mol Cell Biol, (2005 Apr)

Abstract: The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

PubMed ID: 15798197 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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