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National Institute of Environmental Health Sciences

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Publication Detail

Title: Functions and regulation of the multitasking FANCM family of DNA motor proteins.

Authors: Xue, Xiaoyu; Sung, Patrick; Zhao, Xiaolan

Published In Genes Dev, (2015 Sep 01)

Abstract: Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes.

PubMed ID: 26341555 Exiting the NIEHS site

MeSH Terms: Animals; DNA Helicases/genetics*; DNA Helicases/metabolism*; DNA Repair; DNA Replication/genetics; Eukaryota/enzymology; Fanconi Anemia/enzymology; Fanconi Anemia/genetics; Genome/genetics; Humans; Plants/enzymology

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