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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment.

Authors: Dodge, L E; Williams, P L; Williams, M A; Missmer, S A; Souter, I; Calafat, A M; Hauser, R; EARTH Study Team

Published In Reprod Toxicol, (2015 Dec)

Abstract: Limited evidence suggests that male exposure to ubiquitous environmental phthalates may result in poor reproductive outcomes among female partners.This analysis included male-female couples undergoing in vitro fertilization (IVF) and/or intrauterine insemination (IUI). We evaluated associations between the geometric mean of paternal specific gravity-adjusted urinary phthalate concentrations prior to the female partners' cycle and fertilization, embryo quality, implantation, and live birth using generalized linear mixed models.Two-hundred eighteen couples underwent 211 IVF and 195 IUI cycles. Trends were observed between paternal urinary mono-3-carboxypropyl phthalate (MCPP; P=0.01) and mono(carboxyoctyl) phthalate (MCOP; P=0.01) and decreased odds of implantation. MCPP and MCOP were also associated with decreased odds of live birth following IVF (P=0.01 and P=0.04, respectively), and monobutyl phthalate above the first quartile was significantly associated with decreased odds of live birth following IUI (P=0.04). However, most urinary phthalate metabolites were not associated with these reproductive outcomes.Selected phthalates were associated with decreased odds of implantation and live birth.

PubMed ID: 26456810 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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