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Publication Detail

Title: Enzymatic cleavage of histone H3: a new consideration when measuring histone modifications in human samples.

Authors: Howe, Caitlin G; Gamble, Mary V

Published In Clin Epigenetics, (2015)

Abstract: Histone modifications are increasingly being used as biomarkers of cancer prognosis and survival. However, we identified a cleavage product of histone H3 in human peripheral blood mononuclear cells, which interferes with measures of certain H3 modifications. Therefore, the potential for enzymatic cleavage of histones should be considered when measuring histone modifications in human samples. Furthermore, the enzymatic cleavage of human H3 is itself a fascinating area of research and two important questions remain to be answered: 1) Does cleavage of human H3 occur in vivo, as it does in other organisms? and 2) Does it serve a biologically important function?

PubMed ID: 25628766 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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