Title: Effective molarity in a nucleic acid-controlled reaction.
Authors: Catalano, Michael J; Price, Nathan E; Gates, Kent S
Published In Bioorg Med Chem Lett, (2016 06 01)
Abstract: Positioning of reactive functional groups within a DNA duplex can enable chemical reactions that otherwise would not occur to an appreciable extent. However, few studies have quantitatively defined the extent to which the enforced proximity of reaction partners in duplex DNA can favor chemical processes. Here, we measured substantial effective molarities (as high as 25M) afforded by duplex DNA to a reaction involving interstrand cross-link formation between 2'-deoxyadenosine and a 2-deoxyribose abasic (Ap) site.
PubMed ID: 27117430
MeSH Terms: DNA/chemistry*; Deoxyadenosines/chemistry*; Deoxyribose/chemistry*; Nucleic Acid Conformation; Structure-Activity Relationship