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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

Authors: Woeller, Collynn F; Thatcher, Thomas H; Van Twisk, Daniel; Pollock, Stephen J; Croasdell, Amanda; Hopke, Philip K; Xia, Xiaoyan; Thakar, Juilee; Sime, Patricia J; Mallon, Timothy M; Utell, Mark J; Phipps, Richard P

Published In J Occup Environ Med, (2016 Aug)

Abstract: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs).MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model.Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified.Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

PubMed ID: 27501109 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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