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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.

Authors: Jones, Dean P; Walker, Douglas I; Uppal, Karan; Rohrbeck, Patricia; Mallon, Col Timothy M; Go, Young-Mi

Published In J Occup Environ Med, (2016 Aug)

Abstract: The aim of this study is to use high-resolution metabolomics (HRM) to identify metabolic pathways and networks associated with tobacco use in military personnel.Four hundred deidentified samples obtained from the Department of Defense Serum Repository were classified as tobacco users or nonusers according to cotinine content. HRM and bioinformatic methods were used to determine pathways and networks associated with classification.Eighty individuals were classified as tobacco users compared with 320 nonusers on the basis of cotinine levels at least 10 ng/mL. Alterations in lipid and xenobiotic metabolism, and diverse effects on amino acid, sialic acid, and purine and pyrimidine metabolism were observed. Importantly, network analysis showed broad effects on metabolic associations not simply linked to well-defined pathways.Tobacco use has complex metabolic effects that must be considered in evaluation of deployment-associated environmental exposures in military personnel.

PubMed ID: 27501098 Exiting the NIEHS site

MeSH Terms: Cotinine/blood*; Humans; Metabolic Networks and Pathways*; Metabolomics; Military Personnel*; Smoking; Tobacco Use/adverse effects*

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