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National Institute of Environmental Health Sciences

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Publication Detail

Title: The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells.

Authors: Borrello, M A; Palis, J; Phipps, R P

Published In Int Rev Immunol, (2001 Feb)

Abstract: For decades, numerous investigators have reported derivation of macrophage-like cells from CD5(+) pre-B cell lymphomas. Recently, it has become clear that biphenotypic CD5(+) B/macrophage cells are not a spurious result of malignancy. Indeed, the existence of normal biphenotypic cells with CD5(+) B lymphocyte and macrophage characteristics has been demonstrated in the mouse. This review considers normal B/macrophage cell function in an evolutionary context where a primitive, flexible cell type could perform dual roles in adaptive and innate immunity.

PubMed ID: 11342302 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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