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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.

Authors: Duran, Charity G; Burbank, Allison J; Mills, Katherine H; Duckworth, Heather R; Aleman, Maria M; Kesic, Matthew J; Peden, David B; Pan, Yinghao; Zhou, Haibo; Hernandez, Michelle L

Published In Respir Res, (2016 07 22)

Abstract: UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation. TRIAL REGISTRATION: NCT01625130 . Registered 19 June, 2012.

PubMed ID: 27450419 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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