Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: High butter-fat diet and bisphenol A additively impair male rat spermatogenesis.

Authors: Tarapore, Pheruza; Hennessy, Max; Song, Dan; Ying, Jun; Ouyang, Bin; Govindarajah, Vinothini; Leung, Yuet-Kin; Ho, Shuk-Mei

Published In Reprod Toxicol, (2017 Mar)

Abstract: Exposure to xenoestrogens is a probable cause of male infertility in humans. Consumption of high-fat diets and exposure to bisphenol A (BPA) is pervasive in America. Here, we test the hypothesis that gestational exposure to high dietary fats and/or BPA disrupt spermatogenesis in adulthood. Sprague-Dawley rats were fed diets containing 10kcal% butter fat (AIN), 39kcal% butter fat (HFB), or 39kcal% olive oil (HFO), with or without BPA (25μg/kg body weight/day) during pregnancy. One group of male offspring received testosterone (T)- and estradiol-17β (E2)-filled implants or sham-implants from postnatal day (PND)70-210. Another group was naturally aged to 18 months. We found that adult males with gestational exposure to BPA, HFB, or HFB+BPA, in both the aged group and the T+E2-implanted group, exhibited impairment of spermatogenesis. In contrast, gestational exposure to HFO or HFO+BPA did not affect spermatogenesis. Sham-implanted, gestational exposed groups also had normal spermatogenesis. Loss of ERα expression in round spermatids and premature expression of protamine-1 in diplotene spermatocytes were features associated with impaired spermatogenesis. Compared with the single-treatment groups, the HFB+BPA group experienced more severe effects, including atrophy.

PubMed ID: 27658648 Exiting the NIEHS site

MeSH Terms: Animals; Benzhydryl Compounds/toxicity*; Butter; Diet, High-Fat/adverse effects*; Dose-Response Relationship, Drug; Environmental Pollutants/toxicity*; Estradiol/administration & dosage; Estradiol/pharmacology; Female; Male; Maternal Exposure/adverse effects*; Olive Oil; Phenols/toxicity*; Pregnancy; Prenatal Exposure Delayed Effects/chemically induced*; Prenatal Exposure Delayed Effects/physiopathology; Rats, Sprague-Dawley; Spermatogenesis/drug effects*; Testosterone/administration & dosage; Testosterone/pharmacology

Back
to Top
Last Reviewed: October 07, 2024