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Publication Detail

Title: Cancer cells activate damage-tolerant and error-prone DNA synthesis.

Authors: Mutter-Rottmayer, Elizabeth; Gao, Yanzhe; Vaziri, Cyrus

Published In Mol Cell Oncol, (2016)

Abstract: Trans-lesion synthesis (TLS) is a DNA damage-tolerant and error-prone mode of DNA replication. Recent work shows that many cancer cells coopt an aberrantly expressed germ cell protein, melanoma antigen-A4 (MAGE-A4), to activate TLS. MAGE-A4-induced "pathological TLS" provides a potential mechanism through which neoplastic cells can tolerate intrinsic and therapeutic genotoxicity while acquiring mutability.

PubMed ID: 28090576 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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