Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.

Authors: Choe, Katherine N; Moldovan, George-Lucian

Published In Mol Cell, (2017 Feb 02)

Abstract: Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

PubMed ID: 28157503 Exiting the NIEHS site

MeSH Terms: Animals; DNA Replication*; DNA-Directed DNA Polymerase/metabolism; Genomic Instability; Humans; Models, Molecular; Proliferating Cell Nuclear Antigen/chemistry*; Proliferating Cell Nuclear Antigen/metabolism*; Protein Conformation

to Top