Title: Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.
Authors: Choe, Katherine N; Moldovan, George-Lucian
Published In Mol Cell, (2017 Feb 02)
Abstract: Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.
PubMed ID: 28157503
MeSH Terms: Animals; DNA Replication*; DNA-Directed DNA Polymerase/metabolism; Genomic Instability; Humans; Models, Molecular; Proliferating Cell Nuclear Antigen/chemistry*; Proliferating Cell Nuclear Antigen/metabolism*; Protein Conformation