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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

Authors: Kresovich, Jacob K; Zhang, Zhou; Fang, Fang; Zheng, Yinan; Sanchez-Guerra, Marco; Joyce, Brian T; Zhong, Jia; Chervona, Yana; Wang, Sheng; Chang, Dou; McCracken, John P; Díaz, Anaite; Bonzini, Matteo; Carugno, Michele; Koutrakis, Petros; Kang, Choong-Min; Bian, Shurui; Gao, Tao; Byun, Hyang-Min; Schwartz, Joel; Baccarelli, Andrea A; Hou, Lifang

Published In Biomarkers, (2017 Sep)

Abstract: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.We examine the relationship between global histone concentrations and various markers of blood pressure.Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models.H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP.Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.

PubMed ID: 28678539 Exiting the NIEHS site

MeSH Terms: Activities of Daily Living*; Adolescent; Adult; Air Pollution; Beijing; Blood Pressure Determination/methods*; Blood Pressure*; Cardiovascular Diseases; Circadian Rhythm; Epigenomics; Histone Code/physiology*; Humans; Middle Aged; Motor Vehicles; Young Adult

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