Title: Transitions from Ideal to Intermediate Cholesterol Levels may vary by Cholesterol Metric.

Authors: Engeda, Joseph C; Holliday, Katelyn M; Hardy, Shakia T; Chakladar, Sujatro; Lin, Dan-Yu; Talavera, Gregory A; Howard, Barbara V; Daviglus, Martha L; Pirzada, Amber; Schreiner, Pamela J; Zeng, Donglin; Avery, Christy L

Published In Sci Rep, (2018 Feb 09)

Abstract: To examine the ability of total cholesterol (TC), a low-density lipoprotein cholesterol (LDL-C) proxy widely used in public health initiatives, to capture important population-level shifts away from ideal and intermediate LDL-C throughout adulthood. We estimated age (≥20 years)-, race/ethnic (Caucasian, African American, and Hispanic/Latino)-, and sex- specific net transition probabilities between ideal, intermediate, and poor TC and LDL-C using National Health and Nutrition Examination Survey (2007-2014; N = 13,584) and Hispanic Community Health Study/Study of Latinos (2008-2011; N = 15,612) data in 2016 and validated and calibrated novel Markov-type models designed for cross-sectional data. At age 20, >80% of participants had ideal TC, whereas the race/ethnic- and sex-specific prevalence of ideal LDL-C ranged from 39.2%-59.6%. Net transition estimates suggested that the largest one-year net shifts away from ideal and intermediate LDL-C occurred approximately two decades earlier than peak net population shifts away from ideal and intermediate TC. Public health and clinical initiatives focused on monitoring TC in middle-adulthood may miss important shifts away from ideal and intermediate LDL-C, potentially increasing the duration, perhaps by decades, that large segments of the population are exposed to suboptimal LDL-C.

PubMed ID: 29426885

MeSH Terms: No MeSH terms associated with this publication