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Publication Detail

Title: Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis.

Authors: Cohen, Douglas R; Townsend, Craig A

Published In Angew Chem Int Ed Engl, (2018 05 14)

Abstract: Despite the identification of a β-hydroxyhexaene produced by the enediyne polyketide synthases (PKSs), the post-PKS biosynthetic steps to the individual members of this antitumor and antibiotic family remain largely unknown. The massive biosynthetic gene clusters (BGCs) that direct the formation of each product caution that many steps could be required. It was recently demonstrated that the enediyne PKS in the dynemicin A BGC from Micromonospora chersina gives rise to both the anthraquinone and enediyne halves of the molecule. We now present the first evidence for a mid-pathway intermediate in dynemicin A biosynthesis, an iodoanthracene bearing a fused thiolactone, which was shown to be incorporated selectively into the final product. This unusual precursor reflects just how little is understood about these biosynthetic pathways, yet constrains the mechanisms that can act to achieve the key heterodimerization to the anthraquinone-containing subclass of enediynes.

PubMed ID: 29512267 Exiting the NIEHS site

MeSH Terms: Anthracenes/chemistry; Anthracenes/metabolism*; Anthraquinones/chemistry; Anthraquinones/metabolism*; Enediynes/chemistry; Enediynes/metabolism*; Molecular Structure; Multigene Family

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