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Title: Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors.

Authors: Mishra, Birendra; Lawson, Gregory W; Ripperdan, Ryan; Ortiz, Laura; Luderer, Ulrike

Published In Radiat Res, (2018 Aug)

Abstract: Astronauts traveling in deep space are exposed to high-charge and energy (HZE) particles from galactic cosmic rays. We have previously determined that irradiation of adult female mice with iron HZE particles induces DNA double-strand breaks, oxidative damage and apoptosis in ovarian follicles, causing premature ovarian failure. These effects occur at lower doses than with conventional photon irradiation. Ovarian failure with resultant loss of negative feedback and elevated levels of gonadotropin hormones is thought to play a role in the pathophysiology of ovarian cancer. Therefore, we hypothesized that charged-iron-particle irradiation induces ovarian tumorigenesis in mice. In this study, three-month-old female mice were exposed to 0 cGy (sham) or 50 cGy iron ions and aged to 18 months. The 50 cGy irradiated mice had increased weight gain with age and lack of estrous cycling, consistent with ovarian failure. A total of 47% and 7% of mice irradiated with 50 cGy had unilateral and bilateral ovarian tumors, respectively, whereas 14% of mice in the 0 cGy group had unilateral tumors. The tumors contained multiple tubular structures, which were lined with cells positive for the epithelial marker cytokeratin, and had few proliferating cells. In some tumors, packets of cells between the tubular structures were immunopositive for the granulosa cell marker FOXL2. Based on these findings, tumors were diagnosed as tubular adenomas or mixed tubular adenoma/granulosa cell tumors. In conclusion, charged-iron-particle-radiation induces ovarian tumors in mice, raising concerns about ovarian tumors as late sequelae of deep space travel in female astronauts.

PubMed ID: 29781764 Exiting the NIEHS site

MeSH Terms: Animals; Astronauts; Body Weight/radiation effects; Carcinoma, Ovarian Epithelial; Cosmic Radiation/adverse effects*; DNA Damage; Dose-Response Relationship, Radiation; Epithelial Cells/pathology; Epithelial Cells/radiation effects; Estrous Cycle/radiation effects; Extraterrestrial Environment*; Female; Iron/adverse effects*; Mice; Mice, Inbred C57BL; Neoplasms, Glandular and Epithelial/etiology*; Neoplasms, Glandular and Epithelial/genetics; Neoplasms, Glandular and Epithelial/pathology; Neoplasms, Glandular and Epithelial/physiopathology; Neoplasms, Radiation-Induced/etiology*; Neoplasms, Radiation-Induced/genetics; Neoplasms, Radiation-Induced/pathology; Neoplasms, Radiation-Induced/physiopathology; Ovarian Neoplasms/etiology*; Ovarian Neoplasms/genetics; Ovarian Neoplasms/pathology; Ovarian Neoplasms/physiopathology; Ovary/pathology; Ovary/radiation effects

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