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Publication Detail

Title: Pathophysiology of Eosinophilic Esophagitis.

Authors: O'Shea, Kelly M; Aceves, Seema S; Dellon, Evan S; Gupta, Sandeep K; Spergel, Jonathan M; Furuta, Glenn T; Rothenberg, Marc E

Published In Gastroenterology, (2018 Jan)

Abstract: Eosinophilic esophagitis is an emerging disease that is distinguished from gastroesophageal reflux disease by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23 (CAPN14). Rare genetic syndromes have uncovered the contribution of barrier disruption, mediated in part by defective desmosomes and dysregulated transforming growth factor beta production and signaling, to eosinophilic esophagitis pathophysiology. Experimental modeling has defined a cooperative role of activated eosinophils, mast cells, and the cytokines IL-5 and IL-13, mediated by allergic sensitization to multiple foods. Understanding these processes is opening the way to better treatment based on disrupting allergic inflammatory and type 2 cytokine-mediated responses, including anti-cytokine therapeutics and dietary therapy.

PubMed ID: 28757265 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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