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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling.

Authors: Liang, Yaqin; Lang, Anna L; Zhang, Jian; Chen, Jing; Wang, Kai; Chen, Liya; Beier, Juliane I; Qian, Yan; Cai, Lu

Published In Chem Res Toxicol, (2018 Jun 18)

Abstract: Obesity, usually caused by high fat diets (HFD), is a major public health issue worldwide, causing obesity associated cardiomyopathy. Moreover, the environmental toxicant vinyl chloride (VC) can exacerbate HFD-induced fatty liver disease. However, whether VC serves to enhance obesity-associated cardiomyopathy remains unclear. This study aims to investigate the interaction of western diet (WD) containing relatively low fat (42%) with VC on cardiac remodeling and its underling mechanisms. Adult male C57BL/6J mice were exposed to WD coinhalation of low-dose VC (<1 ppm/d) for 12 weeks. Results showed that WD feeding for 12 weeks caused slight cardiac systolic dysfunction without significant hypertrophy or fibrosis, even with VC. Nevertheless, WD upregulated NF-κB function and expression of IL-1β and PAI-1, while VC showed no significant impact on these effects. In contrast, WD together with VC significantly increased the expression of CHOP and TGF-β1, key markers for endoplasmic reticulum stress and profibrotic cytokine, respectively. In summary, exposure to low-dose of environmental toxicant VC while a WD is consumed for a relatively short time does not have significant impact on cardiac remodeling except for a mild systolic dysfunction of the heart.

PubMed ID: 29727174 Exiting the NIEHS site

MeSH Terms: Activating Transcription Factor 4/metabolism; Animals; Diet, High-Fat/adverse effects*; Diet, Western/adverse effects*; Endoplasmic Reticulum Stress/drug effects; Environmental Pollutants/toxicity*; Heart/drug effects*; Heart/physiopathology; Hyperlipidemias/chemically induced; Hyperlipidemias/physiopathology; Insulin Resistance; Liver/drug effects; Liver/metabolism; Male; Mice, Inbred C57BL; Myocardium/metabolism*; NF-kappa B p50 Subunit/metabolism; Obesity/chemically induced; Obesity/physiopathology; Serpin E2/metabolism; Transcription Factor CHOP/metabolism; Transforming Growth Factor beta1/metabolism; Ventricular Remodeling/drug effects*; Vinyl Chloride/adverse effects*

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