Title: Oxidative Stress, Intrauterine Growth Restriction, and Developmental Programming of Type 2 Diabetes.
Authors: Rashid, Cetewayo S; Bansal, Amita; Simmons, Rebecca A
Published In Physiology (Bethesda), (2018 09 01)
Abstract: Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.
PubMed ID:
30109821
MeSH Terms: Animals; Birth Weight/physiology; Diabetes Mellitus, Type 2/physiopathology*; Fetal Growth Retardation/physiopathology*; Humans; Oxidative Stress/physiology*