Title: Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.

Authors: Evers, Raymond; Piquette-Miller, Micheline; Polli, Joseph W; Russel, Frans G M; Sprowl, Jason A; Tohyama, Kimio; Ware, Joseph A; de Wildt, Saskia N; Xie, Wen; Brouwer, Kim L R; International Transporter Consortium

Published In Clin Pharmacol Ther, (2018 Nov)

Abstract: Drug transporters are critically important for the absorption, distribution, metabolism, and excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of these pathways by inhibition, induction, genetic polymorphisms, or disease can have profound effects on overall physiology, drug pharmacokinetics, drug efficacy, and toxicity. This white paper provides a review of changes in transporter function associated with acute and chronic disease states, describes regulatory pathways affecting transporter expression, and identifies opportunities to advance the field.

PubMed ID: 29756222

MeSH Terms: Acute Disease*; Animals; Chronic Disease/drug therapy*; Drug Interactions; Drug-Related Side Effects and Adverse Reactions/etiology; Drug-Related Side Effects and Adverse Reactions/metabolism; Humans; Membrane Transport Modulators/metabolism; Membrane Transport Modulators/pharmacology*; Membrane Transport Proteins/drug effects*; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism*; Models, Biological; Pharmaceutical Preparations/metabolism*; Pharmacokinetics*; Risk Assessment