Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: XANES spectroscopy: a promising tool for toxicology: a tutorial.

Authors: Gunter, Karlene K; Miller, Lisa M; Aschner, Michael; Eliseev, Roman; Depuis, Derrick; Gavin, Claire E; Gunte, Thomas E

Published In Neurotoxicology, (2002 Jul)

Abstract: X-ray absorption near edge structure (XANES) spectroscopy can provide information on the oxidation state of metal ions within a biological sample and also the complexes in which it is found. This type of information could be of great use to toxicologists in understanding the mechanism of action of many toxic agents. The prospect of using a sophisticated physical technique such as XANES may be somewhat intimidating for those without a strong physical background. Here, we explain the concepts necessary to understand XANES spectroscopy at a level that can be easily understood by biological scientists without a strong physics background and describe useful sample preparation and data analysis techniques which can be adapted for a variety of applications. Examples are taken from an ongoing study of manganese in brain mitochondria and neuron-like cells.

PubMed ID: 12224754 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top