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Title: In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.

Authors: Storm, Philip A; Townsend, Craig A

Published In Chem Commun (Camb), (2017 Dec 19)

Abstract: Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.

PubMed ID: 29189834 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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