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Publication Detail

Title: System-specific neurodegeneration following glucotoxicity in the C. elegans model.

Authors: Pinkas, Adi; Lawes, Michael; Aschner, Michael

Published In Neurotoxicology, (2018 09)

Abstract: Hyperglycemia-related neuropathy leads to the onset and exacerbation of several pathologies. The C. elegans model has been used to study this phenomenon and its underlying mechanisms using a broad evaluation for neurodegeneration. Here, we report a system-specific susceptibility for glucotoxicity, namely the dopaminergic, glutamatergic and cholinergic system. Under high-glucose conditions, these systems (and not the serotonergic or GABAergic) were impaired, as observed by evaluating the fluorescent signal in GFP-tagged worm strains. The significance and implications of unequal susceptibility for glucotoxicity in the nervous system is discussed.

PubMed ID: 30036563 Exiting the NIEHS site

MeSH Terms: Acetylcholine/metabolism; Animals; Caenorhabditis elegans; Dopamine/metabolism; Glucose/toxicity*; Glutamic Acid/metabolism; Hyperglycemia/metabolism*; Hyperglycemia/pathology*; Neurons/metabolism; Neurons/pathology*

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Last Reviewed: October 07, 2024