Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Multimodal MRI evaluation of parkinsonian limbic pathologies.

Authors: Wang, Ernest W; Du, Guangwei; Lewis, Mechelle M; Lee, Eun-Young; De Jesus, Sol; Kanekar, Sangam; Kong, Lan; Huang, Xuemei

Published In Neurobiol Aging, (2019 04)

Abstract: Previous multimodal magnetic resonance imaging (MRI) studies of parkinsonian syndromes have focused primarily on motor-related basal ganglia structures. The present study investigated MRI changes in nonmotor-related limbic structures in 35 Parkinson's disease, 16 multiple system atrophy parkinsonian subtype, 17 progressive supranuclear palsy, and 37 control subjects. Mean diffusivity (MD), fractional anisotropy, transverse relaxation rate (R2*), quantitative susceptibility mapping, and volume measurements were obtained from the amygdala, hippocampus, and nucleus accumbens (NAc) to examine differences between groups and to test for associations with clinical scores. Compared with controls, Parkinson's disease subjects had lower NAc volume; multiple system atrophy parkinsonian subtype subjects had higher NAc transverse relaxation rate; and progressive supranuclear palsy subjects had higher amygdala and hippocampus MD and lower hippocampus fractional anisotropy (p's ≤ 0.008). Among parkinsonian subjects, amygdala and hippocampus MD associated positively with Unified Parkinson's Disease Rating Scale nonmotor and activities of daily living scores (p's ≤ 0.005). Together, these findings support the inclusion of limbic structures in future MRI studies of parkinsonian syndromes.

PubMed ID: 30739076 Exiting the NIEHS site

MeSH Terms: Aged; Aged, 80 and over; Female; Humans; Limbic System/diagnostic imaging*; Limbic System/pathology*; Magnetic Resonance Imaging*; Male; Middle Aged; Multimodal Imaging*; Multiple System Atrophy; Neuroimaging*; Parkinson Disease/diagnostic imaging*; Parkinson Disease/pathology*; Supranuclear Palsy, Progressive

to Top