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Publication Detail

Title: Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.

Authors: Schlacher, Katharina

Published In J Cell Biol, (2019 03 04)

Abstract: The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. connects ATM's oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy-demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.

PubMed ID: 30782782 Exiting the NIEHS site

MeSH Terms: Adenosine Triphosphate; Ataxia Telangiectasia Mutated Proteins; DNA Repair; Humans; Mitochondria*; Oxygen*; Signal Transduction

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