Title: Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.
Authors: Schlacher, Katharina
Published In J Cell Biol, (2019 03 04)
Abstract: The ataxia-telangiectasia mutated (ATM) gene regulates DNA damage repair, oxidative stress, and mitochondrial processes. In this issue, Chow et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806197) connects ATM's oxidative stress response functions to the sensing of metabolic ATP energetics distinctively important in high energy-demanding Purkinje brain cells, which could explain the most distinct A-T patient feature, cerebellar ataxia.
PubMed ID: 30782782
MeSH Terms: Adenosine Triphosphate; Ataxia Telangiectasia Mutated Proteins; DNA Repair; Humans; Mitochondria*; Oxygen*; Signal Transduction