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Title: Structural and functional changes in the zebrafish (Danio rerio) skeletal muscle after cadmium exposure.

Authors: Avallone, Bice; Agnisola, Claudio; Cerciello, Raimondo; Panzuto, Raffaele; Simoniello, Palma; Cretì, Patrizia; Motta, Chiara Maria

Published In Cell Biol Toxicol, (2015 Dec)

Abstract: This report describes the alterations induced by an environmentally realistic concentration of cadmium in skeletal muscle fibre organization, composition, and function in the teleost zebrafish. Results demonstrate that the ion induces a significant quantitative and qualitative deterioration, disrupting sarcomeric pattern and altering glycoprotein composition. These events, together with a mitochondrial damage, result in a significant reduction in swimming performance. In conclusion, the evidence here collected indicate that in presence of an environmental cadmium contamination, important economic (yields in fisheries/aquaculture), consumer health (fish is an important source of proteins), and ecological (reduced fitness due to reduced swimming performance) consequences can be expected.

PubMed ID: 26715392 Exiting the NIEHS site

MeSH Terms: Animals; Behavior, Animal/drug effects*; Cadmium/toxicity*; Cations, Divalent; Fish Proteins/antagonists & inhibitors; Fish Proteins/biosynthesis; Glycoproteins/antagonists & inhibitors; Glycoproteins/biosynthesis; Male; Mitochondria/drug effects*; Mitochondria/physiology; Muscle Fibers, Skeletal/drug effects*; Muscle Fibers, Skeletal/physiology; Muscle Fibers, Skeletal/ultrastructure; Sarcomeres/drug effects*; Sarcomeres/physiology; Sarcomeres/ultrastructure; Swimming; Water Pollutants, Chemical/toxicity*; Zebrafish

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