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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Replication-Coupled DNA Repair.

Authors: Cortez, David

Published In Mol Cell, (2019 06 06)

Abstract: The replisome quickly and accurately copies billions of DNA bases each cell division cycle. However, it can make errors, especially when the template DNA is damaged. In these cases, replication-coupled repair mechanisms remove the mistake or repair the template lesions to ensure high fidelity and complete copying of the genome. Failures in these genome maintenance activities generate mutations, rearrangements, and chromosome segregation problems that cause many human diseases. In this review, I provide a broad overview of replication-coupled repair pathways, explaining how they fix polymerase mistakes, respond to template damage that acts as obstacles to the replisome, deal with broken forks, and impact human health and disease.

PubMed ID: 31173722 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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