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National Institute of Environmental Health Sciences

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Publication Detail

Title: Formation and cell translocation of carbon nanotube-fibrinogen protein corona.

Authors: Chen, Ran; Radic, Slaven; Choudhary, Poonam; Ledwell, Kimberley G; Huang, George; Brown, Jared M; Chun Ke, Pu

Published In Appl Phys Lett, (2012 Sep 24)

Abstract: The binding of plasma fibrinogen with both single-walled and multi-walled carbon nanotubes (SWNTs and MWNTs) has been examined. Specifically, our absorbance study indicated that MWNTs were coated with multi-layers of fibrinogen to render a "hard protein corona," while SWNTs were adsorbed with thin layers of the protein to precipitate out of the aqueous phase. In addition, static quenching as a result of energy transfer from fluorescently labeled fibrinogen to their nanotube substrates was revealed by Stern-Volmer analysis. When exposed to HT-29 cells, the nanotubes and fibrinogen could readily dissociate, possibly stemming from their differential affinities for the amphiphilic membrane bilayer.

PubMed ID: 23093808 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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