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Publication Detail

Title: Per- and Polyfluoroalkyl Substance Plasma Concentrations and Bone Mineral Density in Midchildhood: A Cross-Sectional Study (Project Viva, United States).

Authors: Cluett, Rachel; Seshasayee, Shravanthi M; Rokoff, Lisa B; Rifas-Shiman, Sheryl L; Ye, Xiaoyun; Calafat, Antonia M; Gold, Diane R; Coull, Brent; Gordon, Catherine M; Rosen, Clifford J; Oken, Emily; Sagiv, Sharon K; Fleisch, Abby F

Published In Environ Health Perspect, (2019 08)

Abstract: Identifying factors that impair bone accrual during childhood is a critical step toward osteoporosis prevention. Exposure to per- and polyfluoroalkyl substances (PFASs) has been associated with lower bone mineral density, but data are limited, particularly in children.We studied 576 children in Project Viva, a Boston-area cohort of mother/child pairs recruited prenatally from 1999 to 2002. We quantified plasma concentrations of several PFASs and measured areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) in midchildhood. We used linear regression to examine associations between plasma concentrations of individual PFASs and aBMD z-score. We used weighted quantile sum (WQS) regression to examine the association of the PFAS mixture with aBMD z-score. All models were adjusted for maternal age, education, annual household income, census tract median household income, and child age, sex, race/ethnicity, dairy intake, physical activity, and year of blood draw.Children were [[Formula: see text]] [Formula: see text] of age. The highest PFAS plasma concentrations were of perfluorooctanesulfonic acid (PFOS) {median [interquartile range (IQR)]: 6.4 (5.6) ng/mL} and perfluorooctanoic acid (PFOA) [median (IQR): 4.4 (3.2) ng/mL]. Using linear regression, children with higher plasma concentrations of PFOA, PFOS, and perfluorodecanoate (PFDA) had lower aBMD z-scores [e.g., [Formula: see text]: [Formula: see text]; 95% confidence interval (CI): [Formula: see text], [Formula: see text] per doubling of PFOA]. The PFAS mixture was negatively associated with aBMD z-score ([Formula: see text]: [Formula: see text]; 95% CI: [Formula: see text], [Formula: see text] per IQR increment of the mixture index).PFAS exposure may impair bone accrual in childhood and peak bone mass, an important determinant of lifelong skeletal health.

PubMed ID: 31433236 Exiting the NIEHS site

MeSH Terms: Alkanesulfonic Acids/blood*; Bone Density/drug effects*; Boston; Caprylates/blood*; Child; Cross-Sectional Studies; Decanoic Acids/blood*; Environmental Exposure/analysis*; Environmental Pollutants/blood*; Female; Fluorocarbons/blood*; Humans; Male

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