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National Institute of Environmental Health Sciences

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Publication Detail

Title: Production of Insecticide Degradates in Juices: Implications for Risk Assessment.

Authors: Radford, Samantha A; Panuwet, Parinya; Hunter Jr, Ronald E; Barr, Dana Boyd; Ryan, P Barry

Published In J Agric Food Chem, (2016 Jun 08)

Abstract: This study was designed to observe the production of degradates of two organophosphorus insecticides and one pyrethroid insecticide in beverages. Purified water, white grape juice, apple juice, and red grape juice were fortified with 500 ng/g malathion, chlorpyrifos, and permethrin, and aliquots were extracted for malathion dicarboxylic acid (MDA), 3,5,6-trichloro-2-pyridinol (TCPy), and 3-phenoxybenzoic acid (3-PBA) several times over a 15 day period of being stored in the dark at 2.5 °C. Overall, first-order kinetics were observed for production of MDA, and statistically significant production of TCPy was also observed. Statistically significant production of 3-phenoxybenzoic acid was not observed. Results indicate that insecticides degrade in food and beverages, and this degradation may lead to preexisting insecticide metabolites in the beverages. Therefore, it is suggested that caution should be exercised when using urinary insecticide metabolites to assess exposure and risk.

PubMed ID: 27213611 Exiting the NIEHS site

MeSH Terms: Chlorpyrifos/chemistry; Fruit and Vegetable Juices/analysis*; Insecticides/chemistry*; Kinetics; Malathion/chemistry; Permethrin/chemistry; Pyrethrins/chemistry; Risk Assessment

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