Title: Association of systemic antimicrobials with the expression of beta-lactamases in bacteria cultured from urological patients.

Authors: Forster, Catherine S; Powell, Eleanor A; DeBurger, Barbara; Courter, Joshua; Haslam, David B; Mortensen, Joel E

Published In Diagn Microbiol Infect Dis, (2019 Aug)

Abstract: Patients with abnormalities of the genitourinary tract are at high risk for infections with antimicrobial-resistant pathogens.All urine cultures ordered by members of the Division of Urology from four quarterly one-week periods were included. All gram-negative bacilli isolated were analyzed using the Check-Points Check-MDR CT103XL assay to identify the presence of genes associated with resistance to beta-lactam antibiotics. Association between the days of antibiotics and the presence of an ESBL-producing organism was determined.One hundred eleven positive cultures were included in this analysis, of which 5 (4.5%) contained ESBL-producing species. Days of systemic antibiotics within 30 days of urine culture was associated with an increased risk of isolating an ESBL-producing pathogen.The overall prevalence of ESBL-producing organisms is low in this cohort. The number of days of systemic antibiotics within 30 days of a urine culture was significantly associated with increased risk of isolating an ESBL-producing organism.

PubMed ID: 30890298

MeSH Terms: Adolescent; Adult; Anti-Bacterial Agents/pharmacology; Anti-Infective Agents/blood*; Child; Child, Preschool; Cohort Studies; Drug Resistance, Multiple, Bacterial/genetics; Electronic Health Records; Gram-Negative Bacteria/drug effects; Gram-Negative Bacteria/enzymology*; Gram-Negative Bacteria/isolation & purification; Humans; Infant; Microbial Sensitivity Tests; Urinary Tract Infections/microbiology*; Young Adult; beta-Lactamases/metabolism*; beta-Lactams/pharmacology