Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Lung cell exposure to secondary photochemical aerosols generated from OH oxidation of cyclic siloxanes.

Authors: King, Benjamin M; Janechek, Nathan J; Bryngelson, Nathan; Adamcakova-Dodd, Andrea; Lersch, Traci; Bunker, Kristin; Casuccio, Gary; Thorne, Peter S; Stanier, Charles O; Fiegel, Jennifer

Published In Chemosphere, (2020 Feb)

Abstract: To study the fate of cyclic volatile methyl siloxanes (cVMS) undergoing photooxidation in the environment and to assess the acute toxicity of inhaled secondary aerosols from cVMS, we used an oxidative flow reactor (OFR) to produce aerosols from oxidation of decamethylcyclopentasiloxane (D5). The aerosols produced from this process were characterized for size, shape, and chemical composition. We found that the OFR produced aerosols composed of silicon and oxygen, arranged in chain agglomerates, with primary particles of approximately 31 nm in diameter. Lung cells were exposed to the secondary organosilicon aerosols at estimated doses of 54-116 ng/cm2 using a Vitrocell air-liquid interface system, and organic gases and ozone exposure was minimized through a series of denuders. Siloxane aerosols were not found to be highly toxic.

PubMed ID: 31683444 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top