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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.

Authors: Nelson, M A; Wymer, J; Clements Jr, N

Published In Cancer Lett, (1996 May 15)

Abstract: Oncogene and tumor suppressor gene mutations are candidate biomarkers for cancer risk assessment and lesion detection. The K-ras oncogene has previously been associated with non-small cell lung cancer (NSCLC), particularly adenocarcinomas in which reported rates of mutation have approached 30-40%. We have analyzed non-malignant lung tissue from patients with lung cancer and primary lung cancers for K-ras gene mutations. Mutations were detected in 32% cancers and 29% non-malignant lung tissue from patients with cancer. The majority of tumors testing positive were adenocarcinoma of the lung. Normal DNA controls, including peripheral blood lymphocytes and normal lung from non-smokers, were negative. The ability to detect genetic alterations in non-malignant lung tissues is consistent with the concept that genetic alterations are involved in field cancerization of the aerodigestive tract.

PubMed ID: 8616804 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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