Title: Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

Authors: Dunlap, Lee E; Azinfar, Arya; Ly, Calvin; Cameron, Lindsay P; Viswanathan, Jayashri; Tombari, Robert J; Myers-Turnbull, Douglas; Taylor, Jack C; Grodzki, Ana Cristina; Lein, Pamela J; Kokel, David; Olson, David E

Published In J Med Chem, (2020 Feb 13)

Abstract: Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-activity relationship study with the explicit goal of identifying novel psychoplastogens. We have discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N,N-dimethylaminoisotryptamine (isoDMT) psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.

PubMed ID: 31977208

MeSH Terms: Animals; Hallucinogens/chemical synthesis; Hallucinogens/chemistry; Hallucinogens/pharmacology*; Mice; Molecular Structure; N,N-Dimethyltryptamine/chemical synthesis; N,N-Dimethyltryptamine/chemistry; N,N-Dimethyltryptamine/pharmacology*; Neuronal Plasticity/drug effects*; Neurons/drug effects*; Structure-Activity Relationship; Zebrafish