Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response.

Authors: Uribe-Herranz, Mireia; Rafail, Stavros; Beghi, Silvia; Gil-de-Gómez, Luis; Verginadis, Ioannis; Bittinger, Kyle; Pustylnikov, Sergey; Pierini, Stefano; Perales-Linares, Renzo; Blair, Ian A; Mesaros, Clementina A; Snyder, Nathaniel W; Bushman, Frederic; Koumenis, Constantinos; Facciabene, Andrea

Published In J Clin Invest, (2020 01 02)

Abstract: Alterations in gut microbiota impact the pathophysiology of several diseases, including cancer. Radiotherapy (RT), an established curative and palliative cancer treatment, exerts potent immune modulatory effects, inducing tumor-associated antigen (TAA) cross-priming with antitumor CD8+ T cell elicitation and abscopal effects. We tested whether the gut microbiota modulates antitumor immune response following RT distal to the gut. Vancomycin, an antibiotic that acts mainly on gram-positive bacteria and is restricted to the gut, potentiated the RT-induced antitumor immune response and tumor growth inhibition. This synergy was dependent on TAA cross presentation to cytolytic CD8+ T cells and on IFN-γ. Notably, butyrate, a metabolite produced by the vancomycin-depleted gut bacteria, abrogated the vancomycin effect. In conclusion, depletion of vancomycin-sensitive bacteria enhances the antitumor activity of RT, which has important clinical ramifications.

PubMed ID: 31815742 Exiting the NIEHS site

MeSH Terms: Animals; Antigen Presentation/genetics; Antigen Presentation/radiation effects*; Antigens, Neoplasm/genetics; Antigens, Neoplasm/immunology*; Butyrates/immunology; CD8-Positive T-Lymphocytes/immunology*; CD8-Positive T-Lymphocytes/pathology; Dendritic Cells/immunology*; Dendritic Cells/pathology; Female; Gastrointestinal Microbiome*/immunology; Gastrointestinal Microbiome*/radiation effects; Mice; Mice, Knockout; Neoplasms, Experimental*/genetics; Neoplasms, Experimental*/immunology; Neoplasms, Experimental*/pathology; Neoplasms, Experimental*/radiotherapy

to Top