Title: Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis.
Authors: Zhang, Jiancheng; Tan, Yunfei; Chang, Lijia; Hammock, Bruce D; Hashimoto, Kenji
Published In J Affect Disord, (2020 06 01)
Abstract: BACKGROUND: Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids might play a role in the pathogenesis of major psychiatric disorders. Here we studied whether expression of sEH protein is altered in the postmortem samples (parietal cortex, and liver) from patients with major psychiatric disorders. METHODS: Protein expression of sEH in the parietal cortex and liver from control, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ) groups was measured. RESULTS: Levels of sEH in the parietal cortex and liver from MDD, BD, and SZ groups were significantly higher than the control group. Interestingly, there was a positive correlation between sEH protein in the parietal cortex and sEH protein the liver in all groups. LIMITATIONS: The small number in each group may limit our interpretation. CONCLUSIONS: This study shows that the increased expression of sEH in the brain and liver might play a role in the pathogenesis of major psychiatric disorders, suggesting a role of brain - liver axis in major psychiatric disorders.
PubMed ID: 32339103
MeSH Terms: Bipolar Disorder*; Brain/metabolism; Depressive Disorder, Major*/genetics; Epoxide Hydrolases/genetics; Epoxide Hydrolases/metabolism; Humans; Liver/metabolism