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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Toxicogenomics in risk assessment: applications and needs.

Authors: Boverhof, Darrell R; Zacharewski, Timothy R

Published In Toxicol Sci, (2006 Feb)

Abstract: Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable insights into toxic mechanisms of action. However, the application of these data into risk assessment practices is still in the early stages of development, and proof of principle experiments have yet to emerge. The following discusses some potential applications as well as impediments that warrant a concerted investigation from all stakeholders in order to facilitate the acceptance and subsequent incorporation of toxicogenomics into regulatory decision making.

PubMed ID: 16221963 Exiting the NIEHS site

MeSH Terms: Animals; Databases, Genetic; Drug Design; Humans; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Risk Assessment/methods; Toxicogenetics*

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