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Title: Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis.

Authors: Curtin, Paul; Austin, Christine; Curtin, Austen; Gennings, Chris; Figueroa-Romero, Claudia; Mikhail, Kristen A; Botero, Tatiana M; Goutman, Stephen A; Feldman, Eva L; Arora, Manish

Published In PLoS Comput Biol, (2020 04)

Abstract: Evolutionarily conserved mechanisms maintain homeostasis of essential elements, and are believed to be highly time-variant. However, current approaches measure elemental biomarkers at a few discrete time-points, ignoring complex higher-order dynamical features. To study dynamical properties of elemental homeostasis, we apply laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) to tooth samples to generate 500 temporally sequential measurements of elemental concentrations from birth to 10 years. We applied dynamical system and Information Theory-based analyses to reveal the longest-known attractor system in mammalian biology underlying the metabolism of nutrient elements, and identify distinct and consistent transitions between stable and unstable states throughout development. Extending these dynamical features to disease prediction, we find that attractor topography of nutrient metabolism is altered in amyotrophic lateral sclerosis (ALS), as early as childhood, suggesting these pathways are involved in disease risk. Mechanistic analysis was undertaken in a transgenic mouse model of ALS, where we find similar marked disruptions in elemental attractor systems as in humans. Our results demonstrate the application of a phenomological analysis of dynamical systems underlying elemental metabolism, and emphasize the utility of these measures in characterizing risk of disease.

PubMed ID: 32294079 Exiting the NIEHS site

MeSH Terms: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis/metabolism*; Animals; Biomarkers/metabolism; Child; Child, Preschool; Computational Biology; Copper/analysis*; Copper/blood; Copper/urine; Female; Homeostasis; Humans; Infant; Male; Mass Spectrometry; Mice; Mice, Transgenic; Middle Aged; ROC Curve; Risk; Superoxide Dismutase-1/genetics; Superoxide Dismutase-1/metabolism; Tooth/metabolism*

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