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National Institute of Environmental Health Sciences

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Publication Detail

Title: Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein.

Authors: Kim, Hye-Young; Pratt, Derek A; Seal, Jennifer R; Wijtmans, Maikel; Porter, Ned A

Published In J Med Chem, (2005 Nov 3)

Abstract: Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

PubMed ID: 16250637 Exiting the NIEHS site

MeSH Terms: Antioxidants/chemical synthesis*; Antioxidants/chemistry; Humans; Lipid Peroxidation*; Lipoproteins, LDL/blood; Lipoproteins, LDL/chemistry*; Pyridines/chemical synthesis*; Pyridines/chemistry; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Structure-Activity Relationship; Tryptophan/chemistry; alpha-Tocopherol/blood; alpha-Tocopherol/chemistry*

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