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Title: Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile.

Authors: Braun, Joseph M; Buckley, Jessie P; Cecil, Kim M; Chen, Aimin; Kalkwarf, Heidi J; Lanphear, Bruce P; Xu, Yingying; Woeste, Anastasia; Yolton, Kimberly

Published In BMJ Open, (2020 May 07)

Abstract: PURPOSE: Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health. PARTICIPANTS: We recruited 468 pregnant women (age range: 18-45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11-14). FINDINGS TO DATE: Our new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL). FUTURE PLANS: We will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects. TRIAL REGISTRATION NUMBER: NCT00129324.

PubMed ID: 32385062 Exiting the NIEHS site

MeSH Terms: Absorptiometry, Photon; Adolescent; Adult; Body Composition; Bone Density*; Cardiometabolic Risk Factors*; Child; Environmental Exposure/analysis*; Female; Hazardous Substances/adverse effects; Humans; Infant; Infant, Newborn; Longitudinal Studies; Obesity*; Ohio/epidemiology; Outcome Assessment, Health Care*; Pregnancy; Prospective Studies

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